Clinical Studies on Veratrum Alkaloids

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Abstract
An extensive study of the hypotensive properties of protoveratrine, a pure crystalline ester alkaloid from Veratrum album , has been made in hypertensive and normotensive individuals. This drug is shown to be capable of lowering the blood pressure in hypertension of varied etiologies including essential hypertension, acute or chronic renal disease, malignant hypertension, toxemia of pregnancy, and carcinoma of the adrenal cortex. The relationships between dose and response from single intravenous, continuous intravenous, intramuscular and oral administration have been determined.