Human Monoclonal Autoantibodies That React with Multiple Endocrine Organs

Authors:
  • JSJo Satoh
    Jo Satoh
  • BPBellur S. Prabhakar
    Bellur S. Prabhakar
  • MHMartin V. Haspel
    Martin V. Haspel
  • FGFredda Ginsberg-Fellner
    Fredda Ginsberg-Fellner
  • ANAbner L. Notkins
    Abner L. Notkins
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Abstract
MANY human diseases have an autoimmune component. In some, such as myasthenia gravis1 and Hashimoto's thyroiditis,2 the autoimmune response is predominantly organ-specific. In other diseases, such as systemic lupus erythematosus3 and polyendocrinopathy,4 5 6 the autoimmune response is very broad, involving several different organs. For example, in patients with polyendocrine diseases, autoantibodies have been found that react with the pancreas, thyroid, pituitary, and gastric mucosa.4 5 6 Because of the low titers of these autoantibodies, as well as the polyclonality of serum, it has been difficult to determine whether there is a variety of autoantibodies, each reacting with a different organ, or whether the . . .

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