Identification of a cytokine network sustaining neutrophil and Th17 activation in untreated early rheumatoid arthritis
Authors:
- Rita CascãoRCRita Cascão
- Rita A MouraRMRita A Moura
- Inês PerpétuoIPInês Perpétuo
- Helena CanhãoHCHelena Canhão
- Elsa Vieira-SousaEVElsa Vieira-Sousa
- Ana F MourãoAMAna F Mourão
- Ana M RodriguesARAna M Rodrigues
- Joaquim Polido-PereiraJPJoaquim Polido-Pereira
- Mário V QueirozMQMário V Queiroz
- Henrique S RosárioHRHenrique S Rosário
- Maria M Souto-CarneiroMSMaria M Souto-Carneiro
- Luis GracaLGLuis Graca
Open Access
- 20 October 2010
- journal article
- research article
- Published by Springer Nature in Arthritis Research & Therapy
- Vol. 12 (5) , R196
Abstract
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by sustained synovitis. Recently, several studies have proposed neutrophils and Th17 cells as key players in the onset and perpetuation of this disease. The main goal of this work was to determine whether cytokines driving neutrophil and Th17 activation are dysregulated in very early rheumatoid arthritis patients with less than 6 weeks of disease duration and before treatment (VERA).Keywords
This publication has 38 references indexed in Scilit:
- Modulation of IL-17 and Foxp3 Expression in the Prevention of Autoimmune Arthritis in MicePLOS ONE, 2010
- Prolonged, granulocyte–macrophage colony-stimulating factor-dependent, neutrophil survival following rheumatoid synovial fibroblast activation by IL-17 and TNFalphaArthritis Research & Therapy, 2008
- Recent developments in the immunobiology of rheumatoid arthritisArthritis Research & Therapy, 2008
- Tumor necrosis factor α activates release of B lymphocyte stimulator by neutrophils infiltrating the rheumatoid jointArthritis & Rheumatism, 2007
- Differential expression of RANK, RANK-L, and osteoprotegerin by synovial fluid neutrophils from patients with rheumatoid arthritis and by healthy human blood neutrophilsArthritis Research & Therapy, 2007
- Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptidesJournal of Experimental Medicine, 2006
- IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesisJournal of Clinical Investigation, 1999
- Modified disease activity scores that include twenty-eight-joint counts development and validation in a prospective longitudinal study of patients with rheumatoid arthritisArthritis & Rheumatism, 1995
- The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritisArthritis & Rheumatism, 1988
- Measurement of patient outcome in arthritisArthritis & Rheumatism, 1980