Peri‐implant parameters and C‐reactive protein levels among patients with different obesity levels

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Abstract
Background: It is hypothesized that peri‐implant conditions are worse with increasing severity of obesity, because systemic low‐grade inflammatory marker (C‐reactive protein [CRP]) is higher in severe form of obese individuals.Purpose: The aim of the cross‐sectional retrospective study was to compare clinical and radiographic peri‐implant inflammatory parameters in patients with different levels of obesity and correlate these parameters with CRP levels.Materials and Methods: Eighty‐four patients who participated in this study were divided into 4 groups: class I obese (group 1), class II obese (group 2), class III obese (group 3), and nonobese individuals (group 4) were included. Clinical (plaque index [PI], bleeding on probing [BOP], probing depth [PD]) and radiographic (marginal bone loss [MBL]) peri‐implant parameters were recorded. Serum CRP were quantified using enzyme‐linked immunosorbent assay (ELISA). Clinical peri‐implant parameters and serum CRP concentrations were analyzed using 1‐way analysis of variance. The Pearson correlation coefficient was used to analyze correlations of CRP levels with any of the clinical and radiographic parameters assessed.Results: Peri‐implant PI, BOP, PD, and MBL were significantly higher in group‐1, ‐2, and ‐3 patients as compared to nonobese individuals (P < .05). Peri‐implant PI, BOP, PD, and MBL were significantly higher in obese patients of group‐2 and group‐3 as compared to obese patients in group‐1 (P < .01). Mean PI, BOP, PD, and MBL were comparable between group‐2 and group‐3 patients (P > .05). A significant positive correlations were found between CRP levels and BOP (P = .0148) and PD (P = .0425); and significant negative correlation was found for MBL in group 3, respectively (P = .0212).Conclusion: Clinical and radiographic peri‐implant inflammatory parameters and serum CRP were significantly high in patients with severe form of obesity. Serum CRP levels correlated with peri‐implant bleeding in obese patients. These findings are preliminary and long‐term controlled trials are recommended to support these outcomes.
Funding Information
  • Deanship of Scientific Research, King Saud University (RGP-1438-028)

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