Bone formation on carbon nanotube composite
- 26 October 2010
- journal article
- research article
- Published by Wiley in Journal of Biomedical Materials Research Part A
- Vol. 96A (1) , 75-82
Abstract
The effects of a layer‐by‐layer assembled carbon nanotube composite (CNT‐comp) on osteoblasts in vitro and bone tissue in vivo in rats were studied. The effects of CNT‐comp on osteoblasts were compared against the effects by commercially pure titanium (cpTi) and tissue culture dishes. Cell proliferation on the CNT‐comp and cpTi were similar. However, cell differentiation, measured by alkaline phosphatase activity and matrix mineralization, was better on the CNT‐comp. When implanted in critical‐sized rat calvarial defect, the CNT‐comp permitted bone formation and bone repair without signs of rejection or inflammation. These data indicate that CNT‐comp may be a promising substrate for use as a bone implant or as a scaffold for tissue engineering. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2010.Keywords
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