COMPARISON OF THE HYPOTENSIVE AND OTHER OCULAR EFFECTS OF PROSTAGLANDIN-E2 AND PROSTAGLANDIN-F2-ALPHA ON CAT AND RHESUS-MONKEY EYES

Authors:
  • FSFA STERN
    FA STERN
  • LBLZ BITO
    LZ BITO
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  • 1 January 1982
    • journal article
    • research article
    • Vol. 22  (5) , 588-598
    • PMID:7076404
Abstract
Exogenous or endogenous prostaglandins (PG) can give rise to acute increases in intraocular pressure (IOP) and to the development of flare and other signs of uveitis. Low doses of PGE2 and/or PGF2.alpha. topically applied to rabbit or owl monkey [Aotus trivirgatus] eyes significantly reduce IOP. Presently, topical application of 10 to 500 .mu.g of PGE2 also causes a highly significant IOP reduction in cat eyes lasting up to 48 h with little or no development of flare or miosis, whereas similar application of PGF2.alpha. causes, in addition to an IOP reduction, the development of profound pupillary constriction. Topical application of either PGF2.alpha. or PGE2 to the eyes of rhesus monkeys also causes significant dose-dependent reduction in IOP. The hypotensive response in the rhesus monkey is not associated with detectable flare or consistent pupillary constriction, although at higher PG doses, hypotension tends to be preceded in both species by a brief (15-30 min) hypertensive phase. Eyes of different species show different patterns of IOP, miotic and flare responses to topically applied PG, the only consistent effect being a reduction in IOP. In some species, most notably in primates, a reduction in IOP is the predominant effect of PG. PG, or their analogues, may provide a new approach to the clinical control of IOP and the treatment of [human] glaucoma.

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