In vivonon-ionizing photoacoustic mapping of sentinel lymph nodes and bladders with ICG-enhanced carbon nanotubes
Authors:
- Mansik JeonMJMansik Jeon
- Yunok OhYOYunok Oh
- Hyun Wook KangHKHyun Wook Kang
- Jeehyun KimJKJeehyun Kim
- Chulhong KimChulhong Kim
- Junghwan OhJOJunghwan Oh
- 14 November 2012
- journal article
- Published by IOP Publishing in Physics in Medicine & Biology
- Vol. 57 (23) , 7853-7862
Abstract
We demonstrate the feasibility of mapping a sentinel lymph node (SLN) and urinary bladder by using modified single-walled carbon nanotubes (SWNTs) as a nonionizing photoacoustic (PA) contrast agent. To improve the PA sensitivity, indocyanine green (ICG) was conjugated with SWNTs and the optical absorption of SWNTs-ICG was enhanced by approximately four times compared to that of plain SWNTs at a concentration of 0.3 µM. In vivo PA imaging results showed that the SLN and bladder were clearly visualized due to accumulation of SWNTs-ICG. This implies that the SWNTs-ICG could be potentially utilized to identify SLNs in breast cancer patients and tracking vesicoureteral reflux in combination with PA imaging.Keywords
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