Total Synthesis of the Natural Pyridocoumarins Goniothaline A and B
Authors:
- Young Taek HanYHYoung Taek Han
- Sungwan AhnSASungwan Ahn
- Jeong YoonJYJeong Yoon
- 17 September 2018
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 51 (02) , 552-556
Abstract
In this paper, we report the first total synthesis of goniothaline A and B, which are rare natural pyridocoumarins isolated from Goniothalamus australis. The key feature of the synthesis of goniothaline A is high-yielding silver-catalyzed cycloisomerization to afford the pyridine moiety. In addition, goniothaline B, a natural 8-hydroxyquinoline derivative, is readily synthesized by the regioselective demethylation of goniothaline A.Keywords
Funding Information
- National Research Foundation of Korea (NRF-2017R1C1B1001826)