Expression and function of neural cell adhesion molecule during limb regeneration.
Authors:
- C E MaierCMC E Maier
- M WatanabeMWM Watanabe
- M SingerMSM Singer
- I G McQuarrieIMI G McQuarrie
- J SunshineJSJ Sunshine
- U RutishauserURU Rutishauser
- 1 November 1986
- journal article
- research article
- Published by National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 83 (21) , 8395-8399
Abstract
The neural cell adhesion molecule (NCAM) has been detected in regenerating limb bud of adult newts in addition to brain and peripheral nerves. In the regenerating tissue, NCAM was found primarily on mesenchymal cells and also in wound epidermis. Infusion of Fab fragments of antibodies to NCAM into limb buds at the early blastema stage delayed the regenerative process. Previous studies have indicated that NCAM serves as a homophilic ligand for adhesion among cells that express this molecule and, in doing so, can influence the interaction of nerves with their environment. The expression of NCAM in regenerating limb and the effects of antibody infusion are therefore consistent with the observation that limb regeneration requires interactions among axons and mesenchymal cells.Keywords
This publication has 28 references indexed in Scilit:
- Gangliosides stimulate protein synthesis, growth, and axon number of regenerating limb budsJournal of Comparative Neurology, 1984
- Guidance of optic axons in vivo by a preformed adhesive pathway on neuroepithelial endfeetDevelopmental Biology, 1984
- A nerve‐conditioning lesion accelerates limb regeneration in the newtJournal of Experimental Zoology, 1984
- Schwann cells induce morphological transformation of sensory neurones in vitroNature, 1984
- Occurrence of α2–8 linked polysialosyl units in a neural cell adhesion moleculeBiochemical and Biophysical Research Communications, 1983
- Formation of prechondrogenic mesenchymal cell aggregates in the regenerating newt limbDevelopmental Biology, 1982
- Neural cell adhesion molecule is on embryonic muscle cells and mediates adhesion to nerve cells in vitroNature, 1982
- Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.Proceedings of the National Academy of Sciences, 1979
- Neurotrophic activity of brain extracts in forelimb regeneration of the urodele, TriturusJournal of Experimental Zoology, 1976
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970