Inhibition of Hepatic Glutathione S-Transferases by a Major Endogenous Ligand Substance Present in Uremic Serum
Authors:
- Hisamitsu NakahashiHNHisamitsu Nakahashi
- 1 January 1988
- journal article
- research article
- Published by S. Karger AG in Nephron
- Vol. 49 (4) , 281-283
Abstract
A major endogenous ligand substance present in uremic serum, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid, inhibited the in vitro activity of bovine and rat liver glutathione S-transferases. Our results suggested that endogenous ligand substances retained in uremic serum have some toxic activities other than the inhibition of drug binding to serum protein observed in uremia.Keywords
This publication has 8 references indexed in Scilit:
- Determination of indoxyl sulfate in plasma of patients with renal failure by use of ion-pairing liquid chromatography.Clinical Chemistry, 1986
- PURIFICATION AND CHARACTERIZATION OF HUMAN-PLATELET GLUTATHIONE-S-TRANSFERASE1986
- Profiling of Endogenous Ligand Solutes That Bind to Serum Proteins in Sera of Patients with UremiaNephron, 1986
- Isolation and Characterization of an Endogenous Drug-Binding Inhibitor Present in Uremic SerumNephron, 1986
- Human glutathione S-transferases. Characterization of the anionic forms from lung and placentaBiochemical Journal, 1984
- Hepatic drug metabolism in rats with experimental chronic renal failureBiochemical Pharmacology, 1984
- Glutathione transferase from human erythrocytesArchives of Biochemistry and Biophysics, 1978
- The Non‐Covalent Binding of Small Molecules by LigandinEuropean Journal of Biochemistry, 1976