Adhesion molecule L1 inhibition increases infarct size in cerebral ischemia-reperfusion without change in blood-brain barrier disruption
- 30 May 2021
- journal article
- research article
- Published by Taylor & Francis in Neurological Research
- Vol. 43 (9) , 751-759
Abstract
Neural cell adhesion molecule L1CAM (L1) is involved in neuroprotection. To investigate a possible neuroprotective effect of L1 during ischemia, we determined whether blocking L1 with an antagonist...Keywords
Funding Information
- Li Kashing Foundation (100003 LD030302 to MS)
This publication has 35 references indexed in Scilit:
- Adhesion molecule L1 binds to amyloid beta and reduces Alzheimer's disease pathology in miceNeurobiology of Disease, 2013
- Antibody Fragments Directed against Different Portions of the Human Neural Cell Adhesion Molecule L1 Act as Inhibitors or Activators of L1 FunctionPLOS ONE, 2012
- p53 Opens the Mitochondrial Permeability Transition Pore to Trigger NecrosisCell, 2012
- Embryonic Stem Cell-Derived L1 Overexpressing Neural Aggregates Enhance Recovery after Spinal Cord Injury in MicePLOS ONE, 2011
- Mitochondrial Translocation of p53 Mediates Release of Cytochromecand Hippocampal CA1 Neuronal Death after Transient Global Cerebral Ischemia in RatsThe Journal of Neuroscience, 2006
- The p53 response to DNA damageDNA Repair, 2004
- An optimized triphenyltetrazolium chloride method for identification of cerebral infarctsBrain Research Protocols, 2004
- Reversible middle cerebral artery occlusion without craniectomy in rats.Stroke, 1989
- The microcirculation of rat circumventricular organs and pituitary glandBrain Research Bulletin, 1987
- L1 mono- and polyclonal antibodies modify cell migration in early postnatal mouse cerebellumNature, 1983