Inhibition of Cyclooxygenase-2 Upregulates the Nuclear Factor Erythroid 2-related Factor 2 Signaling Pathway to Mitigate Hepatocyte Ferroptosis in Chronic Liver Injury
Authors:
- Zhu YangZYZhu Yang
- Yang TaiYTYang Tai
- Tian LanTLTian Lan
- Chong ZhaoCZChong Zhao
- Jin-Hang GaoJGJin-Hang Gao
- Cheng-Wei TangCheng-Wei Tang
- Huan TongHuan Tong
Open Access
- 3 March 2025
- journal article
- Published by Xia & He Publishing in Journal of Clinical and Translational Hepatology
- Vol. 000 (000) , 000
Abstract
Ferroptosis plays an essential role in chronic liver diseases, and cyclooxygenase-2 (COX-2) affects liver fibrosis through multiple mechanisms. However, research on COX-2 regulation of ferroptosis in chronic liver injury remains limited. This study aimed to investigate whether and how COX-2 regulates ferroptosis in chronic liver injury.Keywords
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