Identification of piperazine-bisamide GHSR antagonists for the treatment of obesity
Authors:
- Ming YuMYMing Yu
- Mike LizarzaburuMLMike Lizarzaburu
- Holger BeckmannHBHolger Beckmann
- Richard ConnorsRCRichard Connors
- Kang DaiKDKang Dai
- Katrin HallerKHKatrin Haller
- Cong LiCLCong Li
- Lingming LiangLLLingming Liang
- Michelle LindstromMLMichelle Lindstrom
- Ji MaJMJi Ma
- Alykhan MotaniAMAlykhan Motani
- Malgorzata WanskaMWMalgorzata Wanska
- 1 March 2010
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 20 (5) , 1758-1762
Abstract
No abstract availableKeywords
This publication has 32 references indexed in Scilit:
- Ghrelin Induces Abdominal Obesity Via GHS-R-Dependent Lipid RetentionMolecular Endocrinology, 2009
- Fluorine and Rhenium Substituted Ghrelin Analogues as Potential Imaging Probes for the Growth Hormone Secretagogue ReceptorJournal of Medicinal Chemistry, 2009
- Trisubstituted 1,2,4-triazoles as ligands for the ghrelin receptor: On the significance of the orientation and substitution at position 3Bioorganic & Medicinal Chemistry Letters, 2008
- Prevalence of Overweight and Obesity in the United States, 1999-2004JAMA, 2006
- 2,4-Diaminopyrimidine Derivatives as Potent Growth Hormone Secretagogue Receptor AntagonistsJournal of Medicinal Chemistry, 2006
- Expression of ghrelin receptor mRNA in the rat and the mouse brainJournal of Comparative Neurology, 2005
- Synthesis and structure–activity relationships of isoxazole carboxamides as growth hormone secretagogue receptor antagonistsBioorganic & Medicinal Chemistry Letters, 2005
- Roles for ghrelin in the regulation of appetite and body weightCurrent Opinion in Endocrinology, Diabetes and Obesity, 2005
- Public Enemy Number One: Tobacco or Obesity?Science, 2004
- Valvular Heart Disease Associated with Fenfluramine–PhentermineNew England Journal of Medicine, 1997