Baseline characteristics of a multiethnic lupus cohort: PROFILE

Authors:
  • GMG McGwin
    G McGwin
  • MPM Petri
    M Petri
  • JRJ D Reveille
    J D Reveille
  • RRR Ramsey-Goldman
    R Ramsey-Goldman
  • RKR P Kimberly
    R P Kimberly
  • TGthe PROFILE Study Group
    the PROFILE Study Group
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Abstract
Purpose: To report the baseline characteristics of a US multi-ethnic, multi-regional, multi-institution cohort of patients with systemic lupus erythematosus (SLE) and how it was constituted. Methods: Patients with SLE per American college of Rheumatology (ACR) classification criteria, 16 years of age and older, with disease of 10 years or less, of Hispanic (H), African American (AA) or Caucasian (C) ethnicity and living in the geographic catchment areas of the participating institutions (the University of Alabama at Birmingham (UAB), Johns Hopkins University (JHU), The University of Texas-Houston Health Science Center (UTH) were eligible to enter the combined cohort (PROFILE, herein). Data from the individual SLE cohorts were pooled and the PROFILE cohort characteristics examined using descriptive statistics. Variables predictive of renal damage were then examined by logistic regression.