Genomic history of the seventh pandemic of cholera in Africa
Top Cited Papers
- 10 November 2017
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 358 (6364) , 785-789
Abstract
Wave upon wave of disease: The cholera pathogen, Vibrio cholerae , is considered to be ubiquitous in water systems, making the design of eradication measures apparently fruitless. Nevertheless, local and global Vibrio populations remain distinct. Now, Weill et al. and Domman et al. show that a surprising diversity between continents has been established. Latin America and Africa bear different variants of cholera toxin with different transmission dynamics and ecological niches. The data are not consistent with the establishment of long-term reservoirs of pandemic cholera or with a relationship to climate events. Science , this issue p. 785 , p. 789Keywords
Funding Information
- Wellcome Trust (098051)
- Indian Council of Medical Research
- Institut Pasteur
- Laboratoire d’Excellence ‘Integrative Biology of Emerging Infectious Diseases’ (ANR-10-LABX-62-IBEID)
- Institut de Veille Sanitaire
- Fondation Le Roch-Les Mousquetaires
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