Solid-Phase Total Synthesis of Cyclic Decapeptide Phakellistatin 12
Authors:
- 20 May 2008
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 71 (6) , 1059-1062
Abstract
Pakellistatin 12 (1) is a new cancer cell growth inhibitory (P388 ED50 2.8 µg/mL) cyclodecapeptide that was isolated from a marine sponge Phakellia sp. The first total synthesis of compound 1 is reported here using solid-phase methodology with safety-catch linker strategy. For the sequence of amino acids in the cycle, the peptide product was analyzed with a MALDI TOF/TOF instrument, and the structure of the synthetic product was found to be chemically and spectroscopically identical to the natural substance.Keywords
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