The neu Gene: an erb B-Homologous Gene Distinct from and Unlinked to the Gene Encoding the EGF Receptor
Authors:
- 6 September 1985
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 229 (4717) , 976-978
Abstract
The neu oncogene, identified in ethylnitrosourea-induced rat neuroglioblastomas, had strong homology with the erb B gene that encodes the epidermal growth factor receptor. This homology was limited to the region of erb B encoding the tyrosine kinase domain. It was concluded that the neu gene is a distinct novel gene, as it is not coamplified with sequences encoding the EGF receptor in the genome of the A431 tumor line and it maps to human chromosome 17.Keywords
This publication has 19 references indexed in Scilit:
- Autophosphorylation sites on the epidermal growth factor receptorNature, 1984
- Growth factors: The epidermal growth factor receptor gene and its productNature, 1984
- 42,000-molecular weight EGF receptor has protein kinase activityNature, 1984
- Human epidermal growth factor receptor cDNA is homologous to a variety of RNAs overproduced in A431 carcinoma cellsNature, 1984
- Expression Cloning of Human EGF Receptor Complementary DNA: Gene Amplification and Three Related Messenger RNA Products in A431 CellsScience, 1984
- Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cellsNature, 1984
- Amplification and Enhanced Expression of the Epidermal Growth Factor Receptor Gene in A431 Human Carcinoma CellsScience, 1984
- Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequencesNature, 1984
- Report of the committee on the genetic constitution of chromosomes 7, 8 and 9Cytogenetic and Genome Research, 1984
- Title Page / Table of ContentsCytogenetic and Genome Research, 1981