Increased cerebral (R)-[11C]PK11195 uptake and glutamate release in a rat model of traumatic brain injury: a longitudinal pilot study
Authors:
- Hedy FolkersmaHFHedy Folkersma
- Jessica C Foster DingleyJDJessica C Foster Dingley
- Bart Nm van BerckelBBBart Nm van Berckel
- Annemieke RozemullerARAnnemieke Rozemuller
- Ronald BoellaardRBRonald Boellaard
- Marc C HuismanMHMarc C Huisman
- Adriaan A LammertsmaALAdriaan A Lammertsma
- W Peter VandertopWVW Peter Vandertop
- Carla Fm MolthoffCMCarla Fm Molthoff
Open Access
- 1 January 2011
- journal article
- Published by Springer Nature in Journal of Neuroinflammation
- Vol. 8 (1) , 67
Abstract
The aim of the present study was to investigate microglia activation over time following traumatic brain injury (TBI) and to relate these findings to glutamate release.Keywords
This publication has 32 references indexed in Scilit:
- Glial Cell–Mediated Deterioration and Repair of the Nervous System after Traumatic Brain Injury in a Rat Model as Assessed by Positron Emission TomographyJournal of Neurotrauma, 2010
- Two activated stages of microglia and PET imaging of peripheral benzodiazepine receptors with [11C]PK11195 in ratsAnnals of Nuclear Medicine, 2010
- Coupling of the NMDA receptor to neuroprotective and neurodestructive eventsBiochemical Society Transactions, 2009
- Reference Tissue Models and Blood-Brain Barrier Disruption: Lessons from (R)-[11C]PK11195 in Traumatic Brain InjuryJournal of Nuclear Medicine, 2009
- [11C]-DPA-713 and [18F]-DPA-714 as New PET Tracers for TSPO: A Comparison with [11C]-(R)-PK11195 in a Rat Model of Herpes EncephalitisMolecular Imaging and Biology, 2009
- Glutamate induces directed chemotaxis of microgliaEuropean Journal of Neuroscience, 2009
- Blockade of microglial glutamate release protects against ischemic brain injuryExperimental Neurology, 2008
- Agrin Expression during Synaptogenesis Induced by Traumatic Brain InjuryJournal of Neurotrauma, 2008
- Current Aspects of Pathophysiology and Cell Dysfunction after Severe Head InjuryCurrent Pharmaceutical Design, 2001
- Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degenerationBrain Research, 2000