IODINE METABOLISM IN HYDATIDIFORM MOLE AND CHORIOCARCINOMA*†

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Abstract
Thyroid function and the binding of thyroxine in serum were assessed in 2 women with choriocarcinoma and 3 with hydatidiform mole. Women with choriocarcinoma who were excreting chorionic gonadotropin did not exhibit estrogenic effects or altered binding of thyroxine by the thyroxine-binding globulin. Chorionic gonadotropin per se thus appears to play no part in the increase in serum thyroxine-binding characteristic of normal pregnancy. In women with hydatidiform moles, the production of thyroid hormone, as estimated by the thyroidal accumulation of I127 and concentrations of serum protein- bound I131, protein-bound I127 and butanol-extractable I131, reached values found in thyrotoxicosis. These parameters returned to normal in each case after removal of the pathologic conceptus.

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