Polypyrrole Nanocones and Dynamic Piezoelectric Stimulation-Induced Stem Cell Osteogenic Differentiation
- 23 July 2019
- journal article
- research article
- Published by American Chemical Society (ACS) in ACS Biomaterials Science & Engineering
- Vol. 5 (9) , 4386-4392
Abstract
Imitating the physiological microenvironment of living cell and tissues opens new avenues of research in the application of electricity to medical therapies. In this study, dynamic piezoelectric stimulation is generated under dynamic culture due to the piezoelectric effect of polyvinylidene fluoride-polypyrrole (PVDF-PPy) electroactive composite. Combined with PPy nanocones, dynamic piezoelectric signals effectively and continuously provide to cells. In the presence of dynamic piezoelectric stimulation as well as PPy nanocones, PPy-PVDF NS samples show promoted bone mesenchymal stem cells (BMSCs) adhesion, spreading and osteogenic differentiation. Based on the results of this study, PPy nanocones and dynamic piezoelectric stimulation can be administered to modulate cell behavior, paving the way for exploration of cells response to dynamic electrical stimulation.Keywords
Funding Information
- China Postdoctoral Science Foundation (2017M622641)
- National Natural Science Foundation of China (31771080, 51702104, 51772106)
- Natural Science Foundation of Guangdong Province (2016A030308014)
- Technological Projects of Guangzhou (201604020110)
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