Thermodynamic Investigation and Mixed Ligand Complex Formation of 1,4-Bis-(3-aminopropyl)-piperazine and Biorelevant Ligands
Open Access
- 26 November 2012
- journal article
- research article
- Published by Wiley in Bioinorganic Chemistry and Applications
- Vol. 2012, 1-10
Abstract
Thermodynamic parameters for protonation of 1,4-bis(3-aminopropyl)-piperazine (BAPP) and its metal complexation with some divalent metal ions were determined in aqueous solution at constant ionic strength (0.1M NaNO3) using a potentiometric technique. The order of ΔG0 and ΔH0 was found to obey , in accordance with the Irving-Williams order. The formation equilibria of zinc (II) complexes and the ternary complexes Zn(BAPP)L, where L=amino acid, amides, or DNA constituents), have been investigated. Ternary complexes are formed by a simultaneous mechanism. The concentration distribution of the complexes in solution was evaluated as a function of pH. Stoichiometry and stability constants for the complexes formed are reported and discussed. The stability of ternary complexes was quantitatively compared with their corresponding binary complexes in terms of the parameter Δlog K.Keywords
This publication has 30 references indexed in Scilit:
- Coordination properties of bidentate (N,O) and tridentate (N,O,O) heterocyclic alcohols with dimethyltin(IV)Journal of Coordination Chemistry, 2011
- Synthesis and anti-HIV activity of α-thiophenoxy-hydroxyethylamide derivativesEuropean Journal of Medicinal Chemistry, 1999
- Thermochemical investigationJournal of Thermal Analysis and Calorimetry, 1996
- Novel Properties of Cooperative Dinuclear Zinc(II) Ions: The Selective Recognition of Phosphomonoesters and Their P−O Ester Bond Cleavage by a New Dinuclear Zinc(II) CryptateJournal of the American Chemical Society, 1996
- Crystal and Molecular Structure of the [6-Deoxy-6-[(2-(4-imidazolyl)ethyl)amino]- cyclomaltoheptaose]copper(II) Ternary Complex with l-Tryptophanate. Role of Weak Forces in the Chiral Recognition Process Assisted by a MetallocyclodextrinInorganic Chemistry, 1996
- The catalytic carboxyester hydrolysis by a new zinc(II) complex with an alcohol-pendant cyclen (1-(2-hydroxyethyl)-1,4,7,10-tetraazacyclododecane): A novel model for indirect activation of the serine nucleophile by zinc(II) in zinc enzymesJournal of the American Chemical Society, 1995
- Carboxyester Hydrolysis Promoted by a New Zinc(II) Macrocyclic Triamine Complex with an Alkoxide Pendant: A Model Study for the Serine Alkoxide Nucleophile in Zinc EnzymesJournal of the American Chemical Society, 1994
- Chiralität und PflanzenschutzAngewandte Chemie, 1991
- Structure-stability relationship in ternary copper(II) complexes involving aromatic amines and tyrosine or related amino acids. Intramolecular aromatic ring stacking and its regulation through tyrosine phosphorylationJournal of the American Chemical Society, 1985
- The Stereochemistry of Metal Complexes of Nucleic Acid Constituents1977