Insight on multiple morphological abnormalities of sperm flagella in male infertility: what is new?
Authors:
Open Access
- 1 January 2020
- journal article
- review article
- Published by Medknow in Asian Journal of Andrology
- Vol. 22 (3) , 236-245
Abstract
The syndrome of multiple morphological abnormalities of the sperm flagella (MMAF) is a specific kind of asthenoteratozoospermia with a mosaic of flagellar morphological abnormalities (absent, short, bent, coiled, and irregular flagella). MMAF was proposed in 2014 and has attracted increasing attention; however, it has not been clearly understood. In this review, we elucidate the definition of MMAF from a systematical view, the difference between MMAF and other conditions with asthenoteratozoospermia or asthenozoospermia (such as primary mitochondrial sheath defects and primary ciliary dyskinesia), the knowledge regarding its etiological mechanism and related genetic findings, and the clinical significance of MMAF for intracytoplasmic sperm injection and genetic counseling. This review provides the basic knowledge for MMAF and puts forward some suggestions for further investigations.Keywords
This publication has 102 references indexed in Scilit:
- Missense Mutations in SLC26A8, Encoding a Sperm-Specific Activator of CFTR, Are Associated with Human AsthenozoospermiaThe American Journal of Human Genetics, 2013
- Loss of SPEF2 Function in Mice Results in Spermatogenesis Defects and Primary Ciliary Dyskinesia1Biology of Reproduction, 2011
- The ciliary membraneCurrent Opinion in Cell Biology, 2010
- Genetic male infertility and mutation of CATSPER ion channelsEuropean Journal of Human Genetics, 2010
- Gene trap mutation of murine Outer dense fiber protein-2 gene can result in sperm tail abnormalities in mice with high percentage chimaerismBMC Developmental Biology, 2010
- Networking with AKAPs: Context-dependent Regulation of Anchored EnzymesMolecular Interventions, 2010
- Deletions and Point Mutations of LRRC50 Cause Primary Ciliary Dyskinesia Due to Dynein Arm DefectsThe American Journal of Human Genetics, 2009
- DrosophilaBld10 Is a Centriolar Protein That Regulates Centriole, Basal Body, and Motile Cilium AssemblyMolecular Biology of the Cell, 2009
- Mutation of Murine Adenylate Kinase 7 Underlies a Primary Ciliary Dyskinesia PhenotypeAmerican Journal of Respiratory Cell and Molecular Biology, 2009
- Plk4-Induced Centriole Biogenesis in Human CellsDevelopmental Cell, 2007