Antagonistic and synergistic activities of various chemicals on the toxicity of fenarimol to Aspergillus niduluns

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Abstract
A variety of chemicals were tested for their antagonistic, independent, or synergistic effect, on the toxicity of fenarimol to fenarimol‐sensitive and resistant strains of Aspergillus nidulans. The chemicals that antagonised fenarimol toxicity included natural lipids and non‐ionic surfactants; those with synergistic activity were anionic and cationic agents (including dodine), some conventional fungicides, hydrochloric acid, sodium hydroxide, and respiratory inhibitors. All these synergists also potentiated the toxicity of fenarimol to fenarimol‐resistant mutants of A. nidulans. In addition, resistance to fenarimol was negatively correlated with dodine sensitivity. Possible mechanisms of antagonism and synergism are discussed. The results may have implications, for fungicides that inhibit sterol biosynthesis, in respect of their efficacy to plant pathogens.

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