Protective Effects of KW-3902, a Novel Adenosine Al-Receptor Antagonist, against Gentamicin-Induced Acute Renal Failure in Rats.

Authors:
  • HKHideaki Kusaka
    Hideaki Kusaka
  • KSKiyoshi Sato
    Kiyoshi Sato
  • AKAkira Karasawa
    Akira Karasawa
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Abstract
We investigated the possible renal protective effects of KW-3902 (8-(noradamantan-3-yl)-1,3-dipropylxanthine), an adenosine A1-receptor antagonist, against gentamicin (GM)-induced acute renal failure (ARF) in rats. ARF was induced by subcutaneous injection of GM at 80 mg/kg/day for 12 days. KW-3902 (0.001-0.1 mg/kg, p.o., twice daily) attenuated the increases of serum creatinine and urea nitrogen and the decrease of creatinine clearance in rats treated with GM. In contrast, furosemide and trichlormethiazide aggravated the GM-induced nephrotoxicity. These results suggest that KW-3902 can ameliorate the GM-induced ARF and that endogenous adenosine may be involved in GM-induced ARF via the adenosine A1-receptor.