Estimation of intestinal trehalase activity from a laxative threshold of trehalose and lactulose on healthy female subjects

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Abstract
Objective: The purpose of present study is to investigate small intestinal trehalase activity and the ability to utilize trehalose in healthy Japanese subjects. Design: First, transitory laxative thresholds of trehalose and lactulose were estimated for each of 20 Japanese female subjects. Then, according to the difference between two relative laxative thresholds, small intestinal trehalase activity was estimated for each individual subject. Trehalose tolerance tests were then carried out on two groups with lower or higher trehalase activity. Setting: Department of Nutrition, Faculty of Medicine, University of Tokyo. Results: When 30 g of trehalose were administered orally to six subjects with the low trehalase activity, blood glucose and insulin levels scarcely elevated after loading. In contrast, when 50 g of trehalose were administered orally to six subjects with high trehalase activity, blood glucose levels quickly and significantly increased 30 min after loading (PPEuropean Journal Of Clinical Nutrition (2000) 24, 783–788