NUCLEAR LOCALIZATION OF S‐100 PROTEIN

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Abstract
Abstract— S‐100 protein has been found in the nuclei isolated from the brain cortex of rabbit. The nuclear S‐100 constitutes a small portion (0.55 per cent) of the S‐100 present in the cytosol. Most of the large and pale nuclei appear to contain much more S‐100 than the small and dark ones. The nuclear membrane is permeable in vitro to S‐100 in presence of divalent cations. Three forms of S‐100 occur in subnuclear fractions: free S‐100, present in the soluble protein fraction; labile‐bound S‐100, present in the deoxyribonucleoprotein fraction and stable‐bound S‐100, present in the residual or‘nucleolar’fraction. The localization of the S‐100 in those regions of the nucleus that are most active in RNA synthesis provides basic information for further studies on the possible role of this protein on genomic expression in nervous tissue.

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