Pregnancy after Transplantation of Cryopreserved Ovarian Tissue in a Patient with Ovarian Failure after Chemotherapy

Authors:
  • JLJacob Levron
    Jacob Levron
  • TETalia Eldar-Geva
    Talia Eldar-Geva
  • IHIzhar Hardan
    Izhar Hardan
  • EFEduard Fridman
    Eduard Fridman
  • YZYaron Zalel
    Yaron Zalel
  • ESEyal Schiff
    Eyal Schiff
  • JDJehoshua Dor
    Jehoshua Dor
Top Cited Papers
Publisher website
Google Scholar
Abstract
Premenopausal women who undergo high-dose chemotherapy have a very high risk of ovarian failure.1 Cryopreservation of ovarian tissue with subsequent autotransplantation has effectively preserved fertility in an animal model,2 but its efficacy in humans has been uncertain. Eggs that were aspirated from cryopreserved ovarian tissue transplanted in heterotopic sites did not result in a pregnancy.3 A live birth was reported after transplantation of cryopreserved ovarian tissue in a woman who had undergone treatment for Hodgkin's disease; however, since the woman had ovulated before transplantation, it is uncertain whether the egg came from the native ovary or the transplanted ovary.4 A recent report described a live birth after transplantation of fresh ovarian tissue from a fertile woman to her sterile monozygotic twin, but this approach does not involve preservation of fertility and hence is not applicable to women facing sterilizing chemotherapy.5

This publication has 8 references indexed in Scilit: