Genes that Regulate Metastasis and Angiogenesis
Authors:
- 1 October 2000
- journal article
- review article
- Published by Springer Nature in Journal of Neuro-Oncology
- Vol. 50 (1-2) , 71-87
Abstract
Genetic instability and an accumulation of genetic and epigenetic changes during tumor progression lead to an increasingly aggressive and treatment-resistant phenotype, and ultimately metastasis. In...Keywords
This publication has 203 references indexed in Scilit:
- PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate CancerScience, 1997
- Patterns and Emerging Mechanisms of the Angiogenic Switch during TumorigenesisCell, 1996
- Angiogenesis in malignant gliomasGlia, 1995
- Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppressionNature Medicine, 1995
- Requirement of Vascular Integrin α v β 3 for AngiogenesisScience, 1994
- Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivoNature, 1993
- Interleukin-6: An OverviewAnnual Review of Immunology, 1990
- What Is the Evidence That Tumors Are Angiogenesis Dependent?JNCI: Journal of the National Cancer Institute, 1990
- Transformation by Oncogenes Encoding Protein Kinases Induces the Metastatic PhenotypeScience, 1987
- Tumor Angiogenesis: Therapeutic ImplicationsNew England Journal of Medicine, 1971