Single-cell Sequencing Reveals Neutrophil Extracellular Traps in Association with Endotheliopathy and Immunothrombosis in Hepatitis B Virus-related Acute-on-chronic Liver Failure
Authors:
- Xitang LiXLXitang Li
- Suping HaiSHSuping Hai
- Xizhe ZhengXZXizhe Zheng
- Peng HuPHPeng Hu
- Wenhui WuWWWenhui Wu
- Qiang GaoQGQiang Gao
- Junjian HuJHJunjian Hu
- Binghui YuBYBinghui Yu
- Feiyang XuFXFeiyang Xu
- Huiling XiangHXHuiling Xiang
- Qin NingQNQin Ning
- Xiaojing WangXWXiaojing Wang
Open Access
- 10 April 2026
- journal article
- Published by Xia & He Publishing in Journal of Clinical and Translational Hepatology
- Vol. 000 (000) , 000
Abstract
Immunothrombosis, the interplay between immune activation and coagulation, contributes to disease progression in inflammatory disorders. Its role in hepatitis B virus–related acute-on-chronic liver failure (HBV-ACLF) and the involvement of neutrophil extracellular traps (NETs) remain unclear. This study aimed to elucidate NETs-mediated immunothrombosis in HBV-ACLF.Keywords
This publication has 49 references indexed in Scilit:
- Neutrophil Extracellular Traps Induce Endothelial Cell Activation and Tissue Factor Production Through Interleukin-1α and Cathepsin GArteriosclerosis, Thrombosis, and Vascular Biology, 2018
- Neutrophil extracellular traps in immunity and diseaseNature Reviews Immunology, 2017
- Development of diagnostic criteria and a prognostic score for hepatitis B virus-related acute-on-chronic liver failureGut, 2017
- Massively parallel digital transcriptional profiling of single cellsNature Communications, 2017
- Acute-on-chronic liver failure: an updateGut, 2017
- Thrombosis as an intravascular effector of innate immunityNature Reviews Immunology, 2012
- Extracellular DNA traps promote thrombosisProceedings of the National Academy of Sciences, 2010
- Evidence-Based Incorporation of Serum Sodium Concentration Into MELDGastroenterology, 2006
- The Fgl2/fibroleukin prothrombinase contributes to immunologically mediated thrombosis in experimental and human viral hepatitisJournal of Clinical Investigation, 2003
- A model to predict poor survival in patients undergoing transjugular intrahepatic portosystemic shuntsHepatology, 2000