Somatostatin interneurons control the timing of developmental desynchronization in cortical networks
Preprint
Abstract
Synchronous neuronal activity is a hallmark of the early developing brain. In the mouse cerebral cortex, activity decorrelates during the second week of postnatal development, progressively acquiring the characteristic pattern of sparse coding underlying the integration of multidimensional sensory information. The maturation of inhibition seems critical for this process, but the specific types of interneurons involved in this crucial transition of network activity in the developing cortex remain unknown. Using in vivo volumetric and longitudinal two-photon calcium imaging during the period that precedes the change from highly synchronous to decorrelated activity, we identify somatostatin-expressing (SST+) interneurons as critical modulators of this switch. Modulation of the activity of SST+ cells accelerates or delays the decorrelation of cortical network activity, a process that involves regulating the degree of maturation of parvalbumin-expressing (PV+) interneurons. SST+ cells critically link sensory inputs with local circuits controlling the neural dynamics in the developing cortex while modulating the integration of other interneurons into nascent cortical circuits.Keywords
All Related Versions
- Published version: Neuron, 112 (12), 2015.
This publication has 80 references indexed in Scilit:
- Pioneer GABA Cells Comprise a Subpopulation of Hub Neurons in the Developing HippocampusNeuron, 2011
- Developmental maturation of excitation and inhibition balance in principal neurons across four layers of somatosensory cortexNeuroscience, 2011
- GABAergic Interneuron Lineages Selectively Sort into Specific Cortical Layers during Early Postnatal DevelopmentCerebral Cortex, 2010
- The Asynchronous State in Cortical CircuitsScience, 2010
- A robust and high-throughput Cre reporting and characterization system for the whole mouse brainNature Neuroscience, 2009
- Internally Mediated Developmental Desynchronization of Neocortical Network ActivityThe Journal of Neuroscience, 2009
- Sparsification of neuronal activity in the visual cortex at eye-openingProceedings of the National Academy of Sciences, 2009
- Gating multiple signals through detailed balance of excitation and inhibition in spiking networksNature Neuroscience, 2009
- Inhibition and Brain WorkNeuron, 2007
- Recombinant adeno-associated virus purification using novel methods improves infectious titer and yieldGene Therapy, 1999