Chromosome Instability in a Calf with Amelia of Thoracic Limbs
Authors:
- I. SzczerbalISI. Szczerbal
- T. StefaniakTST. Stefaniak
- A. DubielADA. Dubiel
- J. SiembiedaJSJ. Siembieda
- W. NizanskiW. Nizanski
- M. SwitonskiMSM. Switonski
Open Access
- 1 September 2006
- journal article
- case report
- Published by SAGE Publications in Veterinary Pathology
- Vol. 43 (5) , 789-792
Abstract
We report here on a case of a Holstein-Friesian male calf with the congenital total absence of thoracic limbs (amelia). cytogenetic study showed a high rate of chromosome instability, represented by chromosome or chromatid breaks and gaps in 46% of the analyzed metaphase spreads. Moreover, 12% of the spreads appeared to be polypolid. The number of micronuclei also was significantly higher when compared to control animals. This paper discusses the association between chromosome instability and limb malformation.Keywords
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