Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike Trimer
- 24 August 2022
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 96 (16) , e0048022
Abstract
The emergence of the Omicron strain of SARS-CoV-2 caused higher immune escape, raising unprecedented concerns about the effectiveness of antibody therapies and vaccines. In this study, we identified a SARS-CoV-2 neutralizing antibody, 553-49, which neutralizes all variants by targeting a completely conserved novel epitope.Keywords
Funding Information
- MOST | National Key Research and Development Program of China (2019YFA0904400)
- Ministry of Science and Technology of the People's Republic of China (2021YFC2302500)
- Ministry of Science and Technology of the People's Republic of China (2021YFE0201800)
- National Natural Science Foundation of China (3197014)
- National Natural Science Foundation of China (31925010)
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