A Comparison of Enalapril with Hydralazine–Isosorbide Dinitrate in the Treatment of Chronic Congestive Heart Failure
Authors:
- Gary JohnsonGJGary Johnson
- Susan ZiescheSZSusan Ziesche
- Frederick CobbFCFrederick Cobb
- Gary FrancisGFGary Francis
- Felix TristaniFTFelix Tristani
- Raphael SmithRSRaphael Smith
- W. Bruce DunkmanWDW. Bruce Dunkman
- Henry LoebHLHenry Loeb
- Maylene WongMWMaylene Wong
- Geetha BhatGBGeetha Bhat
- Steven GoldmanSGSteven Goldman
- 1 August 1991
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 325 (5) , 303-310
Abstract
To define better the efficacy of vasodilator therapy in the treatment of chronic congestive heart failure, we compared the effects of hydralazine and isosorbide dinitrate with those of enalapril in 804 men receiving digoxin and diuretic therapy for heart failure. The patients were randomly assigned in a double-blind manner to receive 20 mg of enalapril daily or 300 mg of hydralazine plus 160 mg of isosorbide dinitrate daily. The latter regimen was identical to that used with a similar patient population in the effective-treatment arm of our previous Vasodilator—Heart Failure Trial.Keywords
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