Quantitative analysis by microchip capillary electrophoresis – current limitations and problem-solving strategies
Authors:
- 2 November 2007
- journal article
- review article
- Published by Royal Society of Chemistry (RSC) in The Analyst
- Vol. 133 (2) , 167-174
Abstract
Obstacles and possible solutions for the application of microchip capillary electrophoresis in quantitative analysis are described and critically discussed. Differences between the phenomena occurring during conventional capillary electrophoresis and microchip-based capillary electrophoresis are pointed out, with particular focus on electrolysis, bubble formation, clogging, surface interactions, injection and aspects related to the power supply. Current drawbacks are specified and improvements for successful quantitative microchip capillary electrophoresis are suggested.Keywords
This publication has 72 references indexed in Scilit:
- Recent developments in optical detection methods for microchip separationsAnalytical and Bioanalytical Chemistry, 2006
- Micro Total Analysis Systems. Latest Advancements and TrendsAnalytical Chemistry, 2006
- The performance of a microchip-based fiber optic detection technique for the determination of Ca2+ ions in urineSensors and Actuators B: Chemical, 2005
- Recent developments in electrochemical detection for microchip capillary electrophoresisElectrophoresis, 2004
- Recent developments in detection for microfluidic systemsElectrophoresis, 2004
- Detection method for microchip separationsAnalytical and Bioanalytical Chemistry, 2004
- Recent developments in detection methods for microfabricated analytical devicesLab on a Chip, 2001
- Characterisation of a micro-total analytical system for the determination of nitrite with spectrophotometric detectionAnalytica Chimica Acta, 1999
- Planar chips technology for miniaturization and integration of separation techniques into monitoring systemsJournal of Chromatography A, 1992
- A gas chromatographic air analyzer fabricated on a silicon waferIEEE Transactions on Electron Devices, 1979