Porcine Epidemic Diarrhea Virus Inhibits HDAC1 Expression To Facilitate Its Replication via Binding of Its Nucleocapsid Protein to Host Transcription Factor Sp1

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Abstract
The enteric coronavirus porcine epidemic diarrhea virus (PEDV) causes fatal acute intestinal infection in neonatal pigs that rely on innate immune responses. Histone deacetylases (HDACs) play important roles in innate immune regulation.
Funding Information
  • China Postdoctoral Science Foundation (2020M681880)
  • National Natural Science Foundation of China (32072817)
  • Science and Technology Department of Zhejiang Province (2018C02028, YY2018003, 2019SNLF020)
  • Science and Technology Department of Zhejiang Province (2021C02049)

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