The Value of Magnesium in Flush Solutions for Human Cadaveric Kidney Preservation

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Abstract
A cooperative clinical trial was conducted among 5 transplant centers in the western USA to determine the value of magnesium sulfate in intracellular electrolyte flush solutions for hypothermic, human kidney storage [for transplant purposes]. Kidneys from alternate donors were flushed with either Mg-free Euro-Collins'' solution or Mg-containing Collins'' 2 solution. Donor and recipient ages, and mean preservation times were not significantly different between the 2 groups. There was a significantly lower dialysis requirement during the first week in the Mg-containing Collins 2 group (33%) vs. the Euro-Collins group (54%). Function rates and serum creatinine nadirs at 1 mo. were not significantly different. The beneficial effect of magnesium sulfate was more evident when preservation times exceeded 24 h.

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