The Reserve/Maximum Capacity of Melatonin’s Synthetic Function for the Potential Dimorphism of Melatonin Production and Its Biological Significance in Mammals
Open Access
Abstract
In this article, we attempt to classify a potential dimorphism of melatonin production. Thus, a new concept of “reserve or maximum capacity of melatonin synthetic function” is introduced to explain the subtle dimorphism of melatonin production in mammals. Considering ASMT/ASMTL genes in the pseudoautosomal region of sex chromosomes with high prevalence of mutation in males, as well as the sex bias of the mitochondria in which melatonin is synthesized, we hypothesize the existence of a dimorphism in melatonin production to favor females, which are assumed to possess a higher reserve capacity for melatonin synthesis than males. Under physiological conditions, this subtle dimorphism is masked by the fact that cells or tissues only need baseline melatonin production, which can be accomplished without exploiting the full potential of melatonin’s synthetic capacity. This capacity is believed to exceed the already remarkable nocturnal increase as observed within the circadian cycle. However, during aging or under stressful conditions, the reserve capacity of melatonin’s synthetic function is required to be activated to produce sufficiently high levels of melatonin for protective purposes. Females seem to possess a higher reserve/maximum capacity for producing more melatonin than males. Thus, this dimorphism of melatonin production becomes manifest and detectable under these conditions. The biological significance of the reserve/maximum capacity of melatonin’s synthetic function is to improve the recovery rate of organisms from injury, to increase resistance to pathogen infection, and even to enhance their chances of survival by maximizing melatonin production under stressful conditions. The higher reserve/maximum capacity of melatonin synthesis in females may also contribute to the dimorphism in longevity, favoring females in mammals.Keywords
This publication has 115 references indexed in Scilit:
- Exercise Standards for Testing and TrainingCirculation, 2013
- Sequencing ASMT Identifies Rare Mutations in Chinese Han Patients with AutismPLOS ONE, 2013
- Mitochondria and chloroplasts as the original sites of melatonin synthesis: a hypothesis related to melatonin's primary function and evolution in eukaryotesJournal of Pineal Research, 2012
- Neurobiology, Pathophysiology, and Treatment of Melatonin Deficiency and DysfunctionThe Scientific World Journal, 2012
- Mutation screening of ASMT, the last enzyme of the melatonin pathway, in a large sample of patients with Intellectual DisabilityBMC Medical Genetics, 2011
- Genetic variation of melatonin productivity in laboratory mice under domesticationProceedings of the National Academy of Sciences, 2010
- Population genetics of sexually antagonistic mitochondrial mutants under inbreedingJournal of Theoretical Biology, 2009
- Enzymes of the shikimic acid pathway encoded in the genome of a basal metazoan, Nematostella vectensis , have microbial originsProceedings of the National Academy of Sciences, 2008
- Abnormal melatonin synthesis in autism spectrum disordersMolecular Psychiatry, 2007
- On the origin of mitosing cellsJournal of Theoretical Biology, 1967