Development of di-arylated 1,2,4-triazole-based derivatives as therapeutic agents against breast cancer: synthesis and biological evaluation
- 22 July 2024
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in RSC Medicinal Chemistry
- Vol. 15 (9) , 3097-3113
Abstract
The most potent derivative (4q, IC 50 = 4.8 μM) of the newly synthesized diarylated 1,2,4-triazole series displays several hallmarks of apoptosis in the MCF-7 breast cancer cells and favourable metabolic stability in diverse liver microsomes.Keywords
Funding Information
- Anusandhan National Research Foundation (SCP/2022/000121)
- Ministry of Education, India
This publication has 50 references indexed in Scilit:
- Novel Triazoles with Potent and Broad-Spectrum Antifungal Activity In Vitro and In VivoJournal of Medicinal Chemistry, 2023
- Exploiting Coordination Behavior of 7‐Azaindole for Mechanistic Investigation of Chan‐Lam Coupling and Application to 7‐Azaindole Based PharmacophoresChemistry – A European Journal, 2023
- Metal‐free Decarboxylative Annulation of 2‐Aryl‐2‐isocyano‐acetates with Aryldiazonium Salts: General Access to 1,3‐Diaryl‐1,2,4‐triazolesAdvanced Synthesis & Catalysis, 2020
- A Review on the Latest Progress of Chan‐Lam Coupling ReactionAdvanced Synthesis & Catalysis, 2020
- Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase InhibitorJournal of Medicinal Chemistry, 2020
- Mechanistic Development and Recent Applications of the Chan–Lam AminationChemical Reviews, 2019
- Pharmacokinetic evaluation of medicinally important synthetic N,N′ diindolylmethane glucoside: Improved synthesis and metabolic stabilityBioorganic & Medicinal Chemistry Letters, 2019
- Facile One‐Pot Synthesis of Methyl 1‐Aryl‐1H‐1,2,4‐triazole‐3‐carboxylates from Nitrilimines with Vilsmeier ReagentEuropean Journal of Organic Chemistry, 2019
- In-vitro and in-vivo pharmacokinetics of IS01957, p-coumaric acid derivative using a validated LC–ESI–MS/MS method in mice plasmaJournal of Pharmaceutical Investigation, 2017
- Determination of species-difference in microsomal metabolism of amitriptyline using a predictive MRM–IDA–EPI methodChemico-Biological Interactions, 2015