In Vitro Susceptibility Testing Methods for Caspofungin against Aspergillus and Fusarium Isolates
Open Access
- 1 January 2001
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 45 (1) , 327-330
Abstract
We investigated the relevance of prominent reduction in turbidity macroscopically (MIC) and formation of aberrant hyphal tips microscopically (minimum effective concentration; MEC) in measuring the in vitro activity of caspofungin against Aspergillus and Fusarium . Caspofungin generated low MICs and MECs against Aspergillus , but not for Fusarium . While MICs increased inconsistently when the incubation time was prolonged, MEC appeared as a stable and potentially relevant endpoint in testing in vitro caspofungin activity.Keywords
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