A novel SadP-scFv UCHT1 lectibody activates T cells and mediates lysis of Burkitt's lymphoma cells
Open Access
- 20 November 2025
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in RSC Chemical Biology
- Vol. 7 (1) , 81-97
Abstract
We describe the design and characterization of a novel SadP-scFv UCHT1 lectibody, a fusion protein consisting of the lectin SadP, which specifically binds to globotriaosylceramide, and the scFv UCHT1, recognizing the CD3 receptor on T cells.Keywords
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Funding Information
- Deutsche Forschungsgemeinschaft (EXC-2189; Project-ID: 390939984)
- Agence Nationale de la Recherche (Glyco@Alps (ANR-15-IDEX-0002))
- Agence Nationale de la Recherche (Labex Arcane/CBH-EUR-GS (ANR-17-EURE-0003))
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