Crystal structure of casein kinase‐1, a phosphate‐directed protein kinase.
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Open Access
- 1 March 1995
- journal article
- research article
- Published by Springer Nature in The EMBO Journal
- Vol. 14 (5) , 1015-1023
Abstract
The structure of a truncated variant of casein kinase‐1 from Schizosaccharomyces pombe, has been determined in complex with MgATP at 2.0 A resolution. The model resembles the ‘closed’, ATP‐bound conformations of the cyclin‐dependent kinase 2 and the cAMP‐dependent protein kinase, with clear differences in the structure of surface loops that impart unique features to casein kinase‐1. The structure is of unphosphorylated, active conformation of casein kinase‐1 and the peptide‐binding site is fully accessible to substrate.Keywords
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