Neoplasia after Successful Renal Transplantation

Authors:
  • PDP.B. Disler
    P.B. Disler
  • AMA.P. MacPhail
    A.P. MacPhail
  • AMA.M. Meyers
    A.M. Meyers
  • JMJ.A. Myburgh
    J.A. Myburgh
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Abstract
Neoplasia developed in 14 of the first 193 patients to receive renal transplants at the Johannesburg Hospital. No case of reticulum cell sarcoma was diagnosed and an extremely high incidence of squamous carcinoma of the skin occurred. Of the latter patients, 62.5% originally suffered from analgesic nephropathy, suggesting a possible relationship between the two conditions. Transplant recipients who later developed tumours were less likely to experience rejection episodes than other recipients, and this may suggest a generally depressed immune surveillance system in these particular patients.