Nmnat2 protects cardiomyocytes from hypertrophy via activation of SIRT6
Authors:
- Shan-Shan YuSYShan-Shan Yu
- Shao-Rui ChenSCShao-Rui Chen
- Rong-Biao PiRPRong-Biao Pi
- Si GaoSGSi Gao
- Hong LiHLHong Li
- Jian-Tao YeJYJian-Tao Ye
- Pei-Qing LiuPei-Qing Liu
- 20 February 2012
- journal article
- Published by Wiley in FEBS Letters
- Vol. 586 (6) , 866-874
Abstract
The discovery of sirtuins (SIRT), a family of nicotinamide adenine dinucleotide (NAD)‐dependent deacetylases, has indicated that intracellular NAD level is crucial for the hypertrophic response of cardiomyocytes. Nicotinamide mononucleotide adenylyltransferase (Nmnat) is a central enzyme in NAD biosynthesis. Here we revealed that Nmnat2 protein expression and enzyme activity were down‐regulated during cardiac hypertrophy. In neonatal rat cardiomyocytes, overexpression of Nmnat2 but not its catalytically inactive mutant blocked angiotensin II (Ang II)‐induced cardiac hypertrophy, which was dependent on activation of SIRT6 through maintaining the intracellular NAD level. Our results suggested that modulation of Nmnat2 activity may be beneficial in cardiac hypertrophy.Keywords
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