Intronic RNAs constitute the major fraction of the non-coding RNA in mammalian cells
Authors:
- Georges St LaurentGLGeorges St Laurent
- Dmitry ShtokaloDSDmitry Shtokalo
- Michael R TackettMTMichael R Tackett
- Zhaoqing YangZYZhaoqing Yang
- Tatyana EreminaTETatyana Eremina
- Claes WahlestedtCWClaes Wahlestedt
- Silvio Urcuqui-InchimaSUSilvio Urcuqui-Inchima
- Bernd SeilheimerBSBernd Seilheimer
- Timothy A McCaffreyTMTimothy A McCaffrey
- Philipp KapranovPKPhilipp Kapranov
Open Access
- 1 January 2012
- journal article
- Published by Springer Nature in BMC Genomics
- Vol. 13 (1) , 504
Abstract
The function of RNA from the non-coding (the so called “dark matter”) regions of the genome has been a subject of considerable recent debate. Perhaps the most controversy is regarding the function of RNAs found in introns of annotated transcripts, where most of the reads that map outside of exons are usually found. However, it has been reported that the levels of RNA in introns are minor relative to those of the corresponding exons, and that changes in the levels of intronic RNAs correlate tightly with that of adjacent exons. This would suggest that RNAs produced from the vast expanse of intronic space are just pieces of pre-mRNAs or excised introns en route to degradation.Keywords
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