“Dynamite Pills” in the Coronary-Care Unit?

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Abstract
Physicians who have kept close watch upon changing fashions in therapy of cardiogenic shock may have been puzzled by claims of effectiveness for drugs with opposite actions. Thus, pressor agents that stimulate alpha receptors, such as norepinephrine, are used to raise systemic vascular resistance and arterial pressure, whereas alpha-blocking agents such as dibenzylene have also been employed to reduce the intense—and sometimes damaging — peripheral vasoconstriction that also often accompanies the shock state. Evidently, the effects of these really quite opposite therapeutic maneuvers may vary in individual patients, perhaps depending upon their precise hemodynamic status.A not dissimilar situation has . . .