Clonal T cells of pure red-cell aplasia

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Abstract
This study detected clonal T cells in patients with acquired pure red‐cell aplasia (PRCA) by Southern blotting and polymerase chain reaction (PCR). Twenty‐nine adult patients with acquired PRCA were enrolled in this study. Seventeen patients had primary acquired PRCA, while 12 patients had the secondary form. Twenty‐two of 29 (76%) patients demonstrated TCR rearrangement by at least one method. We divided the patients into three groups depending on T‐cell clonality. The CD4/8 ratio of patients who were positive on Southern blotting was significantly lower than that of other groups. Except for the CD4/8 ratio, other laboratory findings did not significantly differ among the three groups. The CD4/8 ratio should be a useful surrogate marker to detect T‐cell clonality. Am. J. Hematol. 79:332–333, 2005.