A mutation in H5 haemagglutinin that conferred human receptor recognition is not maintained stably during duck passage
Open Access
- 3 February 2010
- journal article
- Published by Microbiology Society in Journal of General Virology
- Vol. 91 (6) , 1461-1463
Abstract
A/Hong Kong/213/97 (HK213; H5N1), isolated from a human, binds to both avian- and human-type receptors, due to a haemagglutinin (HA) mutation probably acquired during adaptation to humans. Duck passage of this virus conferred lethality in ducks. Sequence analyses of the duck-passaged virus revealed that its HA gene reverted back to one recognizing only avian-type receptors, and consequently it bound human tissue to a lesser extent. This finding suggests that viruses with human-type receptor specificity are unlikely to be maintained in waterfowl, unlike those with the human-type PB2 mutation, such as H5N1 viruses of the Qinghai Lake lineage.Keywords
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