Regulation of glomerular heparanase expression by aldosterone, angiotensin II and reactive oxygen species
- 9 May 2009
- journal article
- Published by Oxford University Press (OUP) in Nephrology Dialysis Transplantation
- Vol. 24 (9) , 2637-2645
Abstract
Background. Inhibition of the renin–angiotensin–aldosterone system (RAAS) provides renoprotection in adriamycin nephropathy (AN), along with a decrease in overexpression of glomerular heparanase. Angiotensin II (AngII) and reactive oxygen species (ROS) are known to regulate heparanase expression in vivo. However, it is unknown whether this is also the case for aldosterone. Therefore, we further assessed the role of aldosterone, AngII and ROS in the regulation of glomerular heparanase expression.Keywords
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