Gating Deficit Heritability and Correlation With Increased Clinical Severity in Schizophrenia Patients With Positive Family History
Authors:
- Tiffany A GreenwoodTGTiffany A Greenwood
- Gregory A LightGLGregory A Light
- Neal R SwerdlowNSNeal R Swerdlow
- Monica E CalkinsMCMonica E Calkins
- Michael F GreenMGMichael F Green
- Raquel E GurRGRaquel E Gur
- Ruben C GurRGRuben C Gur
- Laura C LazzeroniLLLaura C Lazzeroni
- Keith H NuechterleinKNKeith H Nuechterlein
- Ann OlincyAOAnn Olincy
- Allen D RadantARAllen D Radant
- Larry J SeidmanLSLarry J Seidman
- 1 April 2016
- journal article
- research article
- Published by American Psychiatric Association Publishing in American Journal of Psychiatry
- Vol. 173 (4) , 385-391
Abstract
Objective:The Consortium on the Genetics of Schizophrenia Family Study evaluated 12 primary and other supplementary neurocognitive and neurophysiological endophenotypes in schizophrenia probands and their families. Previous analyses of prepulse inhibition (PPI) and P50 gating measures in this sample revealed heritability estimates that were lower than expected based on earlier family studies. Here the authors investigated whether gating measures were more heritable in multiply affected families with a positive family history compared with families with only a single affected proband (singleton).Method:A total of 296 nuclear families consisting of a schizophrenia proband, at least one unaffected sibling, and both parents underwent a comprehensive endophenotype and clinical characterization. The Family Interview for Genetic Studies was administered to all participants and used to obtain convergent psychiatric symptom information for additional first-degree relatives. Among the families, 97 were multiply aff...Keywords
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