5-Methyltetrahydrofolic Acid as a Mediator in the Formation of Pyridoindoles
Authors:
- 22 November 1974
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 186 (4165) , 741-743
Abstract
Enzymes from chick and rat tissues catalyze the reaction of N -methyltryptamine with 5-methyltetrahydrofolic acid to form 2,3,4,9-tetrahydro-2-methyl-1 H -pyrido[3,4 b ]indole. N,N -Dimethyltryptamine was not formed. With tryptamine as substrate the product is 2,3,4,9-tetrahydro-1 H -pyrido[3,4 b ]indole and not N -methyltryptamine. These pyridoindoles were not formed when S -adenosylmethionine was cosubstrate.Keywords
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